Tacrolimus Topical

What is tacrolimus topical?

Tacrolimus topical is an immunosuppressive agent used to treat and control inflammation and itching of the skin caused by allergies or an overactive immune system in cats and dogs.

It is used off label (extra label) in veterinary medicine. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions very carefully, as their directions may be significantly different from those on the label.

How do I give my pet tacrolimus topical?

• Tacrolimus topical comes in an ointment form.
• Ointments are applied topically directly to the skin. 
• Wash your hands before and after applying this medication or wear gloves.
• Follow product-specific label directions for use.
• Do not allow grooming, chewing, or licking of application site for at least 30 minutes after applying this medication.
• Avoid contact with eyes.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

This medication should take effect within several days, though full effects may not be seen for several weeks.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects ?

Tacrolimus topical may cause the following side effects:

• Mild irritation, itching, or redness at application site

Serious adverse reactions may occur. If any of the following signs develop, stop giving tacrolimus and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
• Weakness, decreased appetite
• Fever, infections
• Abnormal bruising or bleeding

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This is a moderate-acting medication, meaning effects will last several days, though effects may be prolonged in animals with kidney or liver disease.

Are there any risk factors for this medication?

DO NOT USE tacrolimus topical in animals that:

• Are allergic to any of the components or to similar medications

USE WITH CAUTION in pets who:

• Are pregnant, nursing, or used for breeding
• Are taking other immunosuppressive drugs
• Have enlarged lymph nodes

Are there any drug interactions I should be aware of?

The following medications should be used with caution when given with tacrolimus topical:

• Carprofen
• Fenofibrate
• Fluoroquinolones (e.g., enrofloxacin, marbofloxacin, ciprofloxacin)
• Ilunocitinib
• Mitoxantrone
• Oclacitinib
• Prednisolone, prednisone

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects. 
• At home, monitor for any abnormal changes. If these occur, discontinue the medication and contact your veterinarian.

How do I store tacrolimus topical?

• Store the medication in its original container, at room temperature. 
• Keep cap tightly closed.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.