Ophytrium

What is ophytrium?

Ophytrium is an ingredient extracted from Japanese mondo grass (Ophipogon japonicus) that is used in several topical treatments (i.e., Douxo® S3 products). It is used on dogs and cats with oily to flaky skin. It is believed to help control odor and dandruff, soothe and hydrate the skin, maintain the skin barrier, untangle the fur, and soften the coat.

 The U.S. Food and Drug Administration (FDA) does not review non-drug health products (e.g., herbals, nutraceuticals, shampoos, and other supplements) for safety or effectiveness before being sold to the public. Manufacturers of non-drug health products must ensure their products are safe and labeled accurately. The FDA requires that these non-pharmaceuticals contain a disclaimer that says, “This product is not intended to diagnose, treat, cure or prevent any disease.” Health Canada licenses “veterinary health products” after reviewing safety, efficacy, and manufacturing information provided by the manufacturer.  These products are not tested by Health Canada.

Your veterinarian is the best source of information about the safety of non-drug health products in pets. Just because a product is natural does not mean it is safe. All medicines and medicinal plants are potentially toxic if used inappropriately or given at high doses. Supplements can also have side effects, like pharmaceuticals. Few supplements and herbs have been subjected to rigorous scientific trials to determine their efficacy. 

Although the information in this handout may be helpful, it also may be incomplete and may not represent the full range of effects the supplement could have on your pet.

How is ophytrium administered?

• Ophytrium is a topical product applied to the skin as a shampoo, mousse, medicated pad, or to the ear within an ear cleanser solution. Follow your veterinarian’s instructions for correct administration.
• No information is available on how quickly ophytrium takes effect, but studies suggest that topical products containing the ingredient can lead to improvement of itching and redness in 7–21 days.
• Ophytrium is for EXTERNAL USE ONLY. If it contacts your pet’s eyes, flush it out with an eye rinse solution or water and contact your veterinarian.

What if I miss giving my pet the supplement?

If you miss an application, give it as soon as you remember. However, if it is almost time for the next scheduled application, skip the missed one and resume the regular schedule. Do not double up on applications to make up for a missed one.

Are there any potential side effects?

Ophytrium may uncommonly cause the following side effects:

• Increased skin redness and irritation

Other side effects may occur. If you notice anything unusual, discontinue use and contact your veterinarian immediately.

Are there any risk factors for this medication?

Ophytrium should NOT BE USED in patients who are allergic to it. Although no allergic reactions have been reported, sensitivities can develop over time, with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns.

Are there any drug interactions I should be aware of? 

There are no reported interactions with ophytrium. Make sure your veterinarian is aware of any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment. 

Is any monitoring needed with this supplement?

Follow your veterinarian’s recommendations for recheck examinations. At home, monitor for any abnormal changes. If these occur, discontinue the medication and contact your veterinarian.

How do I store ophytrium?

Ophytrium should be stored in the original container at room temperature between 68°F and 77°F (20°C -25°C).

What should I do in case of emergency?

If you suspect an adverse reaction to ophytrium, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.

Adverse effects should also be reported to the FDA or Health Canada.