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Acetic Acid/Boric Acid Topical

What is acetic acid/boric acid topical?

Acetic acid/boric acid topical (brand name Malacetic®) is an antibacterial and antifungal medication used to treat skin infections. It is used to treat surface skin infections caused by bacteria and/or yeast in cats and dogs. Some formulations may be used to treat ear infections.

This medication may be part of a combination product that includes other medications, such as ketoconazole, chlorhexidine, and/or a steroid. This medication is available over the counter (OTC), but should only be used under the direction of a veterinarian. 

It may be used “off label” or “extra label” in other species. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully.

How do I give my pet acetic acid/boric acid topical?

Acetic acid/boric acid topical comes in shampoo, liquid, or wipe form. 

  • Shampoos, liquids (sprays or droppers), and wipes are applied topically (directly onto the skin). 
  • Follow your veterinarian’s directions for the specific product prescribed for your pet.
  • Do not let any animal lick or chew affected sites for at least 30 minutes after application.
  • Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears your pet is feeling better.

What if I miss giving my pet the medication?

Give the missed dose as soon as you remember and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give the pet two doses at once.

Are there any potential side effects from acetic acid/boric acid topical?

Acetic acid/boric acid topical may cause the following side effects:

  • irritation or reddening of skin at application site

The following reactions are rare; if they occur, contact your veterinarian immediately:

  • an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. 

Are there any risk factors for this medication?

  • This medication should be AVOIDED in animals allergic to any component.
  • This medication should be used with CAUTION when given long-term as part of a combination product containing a steroid, as potential systemic effects can occur with long-term steroid use.

Are there any drug interactions I should be aware of?

No known drug interactions have been reported for this medication.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

Your veterinarian may schedule a follow-up visit for after the course of medication is complete to ensure the infection has been cleared and/or do additional tests to ensure this is the right medication for the infection present. In this case, follow your veterinarian’s directions.

How do I store acetic acid/boric acid topical?

  • Store the medication in its original container at room temperature. 
  • Protect from light and moisture. Do not freeze.
  • Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Created on Jun 18, 2024.

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